Seeking people with a bleeding disorder such as Hemophilia or Von Willebrand Disease for a registry to collect health data to address the needs and challenges of people living with bleeding disorders.
Seeking men & women over 18 years old who have a blood disorder or malignancy to investigate normal and abnormal cell growth.
Men and women over 16 years old undergoing transplantation with unlicensed CBUs (cord blood units) will be enrolled. Cord blood units not meeting FDA requirements or not yet approved by the FDA may be used for transplant if the transplant is done as part of a study.
Adult male and female U.S. recipients of allogeneic or autologous HSC transplants or cellular therapies are eligible to participate in the NMDP Research Sample Repository.
Seeking children and young adults 31 years old or younger who have been newly diagnosed with standard risk B-cell Acute Lymphoblastic Leukemia (B-ALL), Down syndrome B ALL or localized B-cell Lymphoblastic Lymphoma (B-LLy) for a study of chemotherapy.
Children and young adults up to age 25 with High-Risk B-cell acute lymphoblastic leukemia (B-ALL) sought for a study of an investigational drug in combination of chemotherapy based on individual disease characteristics to improve 5-year disease-free survival (DFS).
Seeking children and young adults whose CD22+ B-Acute Lymphoblastic Leukemia (B ALL) has come back (relapsed) after treatment or has not responded (refractory) for a study of an investigational drug. While the investigational drug has been approved for use adults with leukemia, it has not yet been approved for use in children.
This study is looking at using different experimental treatment methods for children diagnosed with Acute Myeloid Leukemia (AML) and Down Syndrome (DS) based on how well they respond to their first treatment.